Genomic imprinting in the human placenta

Genomic Imprinting in Human Placenta

Luca Lambertini1,2, Men-Jean Lee3, Carmen J. Marsit4 and Jia Chen1,5,6 1Department of Preventive Medicine, Mount Sinai School of Medicine, New York, 2Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, 3Department of Obstetrics and Gynecology, Indiana University-Purdue University, Indianapolis, 4Department of Pharmacology and Toxicology, Dart...

The Importance of Imprinting in the Human Placenta

As a field of study, genomic imprinting has grown rapidly in the last 20 years, with a growing figure of around 100 imprinted genes known in the mouse and approximately 50 in the human. The imprinted expression of genes may be transient and highly tissue-specific, and there are potentially hundreds of other, as yet undiscovered, imprinted transcripts. The placenta is notable amongst mammalian o...

Genomic Imprinting and Human Reproduction

Limited evolutionary conservation of imprinting in the human placenta.

The epigenetic phenomenon of genomic imprinting provides an additional level of gene regulation that is confined to a limited number of genes, frequently, but not exclusively, important for embryonic development. The evolution and maintenance of imprinting has been linked to the balance between the allocation of maternal resources to the developing fetus and the mother's well being. Genes that ...

Genomic Imprinting

BACKGROUND Genomic imprinting is the inheritance out of Mendelian borders. Many of inherited diseases and human development violates Mendelian law of inheritance, this way of inheriting is studied by epigenetics. AIM The aim of this review is to analyze current opinions and options regarding to this way of inheriting. RESULTS Epigenetics shows that gene expression undergoes changes more com...